Rp-hplc Method for Quantitative Estimation of Olanzapine in Tablet Dosage Forms
نویسندگان
چکیده
A simple RP-HPLC method for the determination of olanzapine in pharmaceutical dosage forms. Numerous HPLC conditions were tested for determination of olanzapine. The best result was achieved by using Capcell pak C-18 (250×4.6mm) 5μm column and a mobile phase consisting of Acetonitrile: Water: Tri ethylamine (60:40:0.1 v/v/v), a flow rate of 1.0 ml/min with ultraviolet detection at 270nm. The retention time of the drug was 6.53 min. The method produced liner responses in the concentration range of 2 to 12μg/ml of olanzapine. The method was found to be applicable for determination of the drug in tablets.
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تاریخ انتشار 2012